Diversity-oriented synthesis of novel polycyclic scaffolds using polymer-bound reagents.
نویسندگان
چکیده
A concise sequence utilizing a Petasis three component reaction followed by a tandem aza-Cope-Mannich cyclization afforded novel polycyclic heterocycles in good yield; alternative iminium cyclization based on a Pictet-Spengler reaction or aminal formation led to divergent pathways affording skeletal diversity.
منابع مشابه
Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion
Nature has exploited medium-sized 8- to 11-membered rings in a variety of natural products to address diverse and challenging biological targets. However, owing to the limitations of conventional cyclization-based approaches to medium-ring synthesis, these structures remain severely underrepresented in current probe and drug discovery efforts. To address this problem, we have established an alt...
متن کاملTwo-directional synthesis as a tool for diversity-oriented synthesis: Synthesis of alkaloid scaffolds
Two-directional synthesis represents an ideal strategy for the rapid elaboration of simple starting materials and their subsequent transformation into complex molecular architectures. As such, it is becoming recognised as an enabling technology for diversity-oriented synthesis. Herein, we provide a thorough account of our work combining two-directional synthesis with diversity-oriented synthesi...
متن کاملDiversity-oriented synthesis of bicyclic and tricyclic alkaloids.
A diversity-oriented synthesis involving a cascade sequence, taking linear aminoalkenes to polycyclic scaffolds reminiscent of natural alkaloids, is presented.
متن کاملSynthesis and characterization of fiber reinforced polymer scaffolds based on natural fibers and polymer for bone tissue engineering application
A wide range of materials and scaffolding fabrication methods for bone tissue engineering have beenexplored recently. Fiber reinforced polymers (FRP) system appears to be a suitable system. By the exclusiveuse of biocompatible or bio-absorbable polymers and fibers, novel generation of scaffolds for applicationsin tissue engineering can be prepared. Mulberry Silk as highlighted...
متن کاملMicrowave-assisted preparation of 4-amino-3-cyano-5-methoxycarbonyl-N-arylpyrazoles as building blocks for the diversity-oriented synthesis of pyrazole-based polycyclic scaffolds.
The synthesis of 4-amino-3-cyano-N-arylpyrazoles A based on a Thorpe-Ziegler cyclization as the key step has been achieved using microwave activation. Via a new diversity-oriented synthetic pathway, these highly functionalized building blocks allowed the access to various heteroaromatic scaffolds such as pyrazolo-pyridines B, pyrazolo-pyrimidines C and pyrazolo-oxadiazoles D. Interestingly, the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical communications
دوره 38 شماره
صفحات -
تاریخ انتشار 2008